Related Experiment Video
Updated: Sep 29, 2026
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Usefulness of CA19-9 versus CA125 for the diagnosis of endometriosis
Tatsuya Harada1, Toshiro Kubota, Takeshi Aso
1Department of Comprehensive Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. t.harada.gyne@tmd.ac.jp
Objective:
To investigate the clinical value of the serum CA19-9 level in comparison with the serum CA125 level for diagnosing and determining the severity of endometriosis.
Design:
Retrospective study.
Setting:
Department of Comprehensive Reproductive Medicine in a university hospital.
Patient(S):
One hundred one women with endometriosis and 22 without endometriosis participated in this study.
Intervention(S):
Blood samples were collected before the operation (laparoscopy, oophrectomy, cystectomy, and/or hysterectomy), and tissue samples of ovarian chocolate cysts were collected during the operation.
Main Outcome Measure(S):
The serum CA19-9 and CA125 levels and the localization of these antigens in ovarian chocolate cysts.
Result(S):
The mean serum CA19-9 levels in patients at all stages of endometriosis were significantly higher than those in patients without endometriosis, and serum CA19-9 levels significantly correlated with the Revised American Fertility Society classification scores. Intense staining of CA19-9 was observed in 15 of the 20 samples of ovarian chocolate cysts.
Conclusion(S):
CA19-9 is a useful marker for determining the severity of endometriosis.
