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DNA Interaction and photonicking properties of DNA-targeted acridine (2,2'-Bipyridine)platinum(II) complexes
Lourdes Gude1, María-José Fernández, Kathryn B Grant
1Departamento de Qui;mica Orgánica, Universidad de Alcalá, 28871-Alcalá de Henares, Madrid, Spain.
Bioorganic & Medicinal Chemistry Letters
|October 10, 2002
Abstract:
Synthesis of two (2,2'-bipyridine)platinum(II) complexes tethered to one or two acridine chromophores is reported. These acridine complexes efficiently unwind and photocleave supercoiled plasmid DNA under physiological conditions of temperature and pH.