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Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands
Wen-Lian Wu1, Mary Ann Caplen, Martin S Domalski
1Schering Plough Research Institute, 2015 Galloping Hill Road, MS 2800, Kenilworth, NJ 07033-0539, USA.
Bioorganic & Medicinal Chemistry Letters
|October 10, 2002
Abstract:
A series of aminoalkylazetidines has been discovered as novel ORL1 receptor ligands. Structure-activity relationships have been investigated at the azetidine N and the alkyl side chain sites. Several potent and selective analogues have been identified.