Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antioxidant status and hearing function in noise-exposed workers.

Peter M Rabinowitz1, John Pierce Wise, Ben Hur Mobo

  • 1Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, 135 College Street, Third Floor, New Haven, CT 06510, USA. peter.rabinowitz@yale.edu

Hearing Research
|October 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Particulate Hexavalent Chromium Inhibits RAD51 Paralogs Necessary for RAD51 Filament Formation and Stabilization During Homologous Recombination Repair.

Occupational Health·2026
Same author

A Survey of DNA Damage in American Alligators (Alligator mississippiensis) in Florida.

Environmental and molecular mutagenesis·2026
Same author

Hexavalent Chromium Oropharyngeal Aspiration Induced Behavior Effects and Essential Metal Dyshomeostasis in Young Hartley Guinea Pigs.

Applied sciences (Basel, Switzerland)·2026
Same author

Challenges to food security in a changing environment: a community-based participatory research study in Casamance, Senegal (West Africa).

Frontiers in public health·2026
Same author

Teaching the Learner to Teach: An Effective and Reproducible Curriculum to Engage Junior Residents as Educators.

The American surgeon·2026
Same author

It's a gator tale: Alligator lung cells resist hexavalent chromium-induced DNA repair inhibition and chromosome instability.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2026
Same journal

TGF-β signaling regulates flat epithelium formation in severely injured adult mouse utricle through epithelial-mesenchymal transition.

Hearing research·2026
Same journal

Membrane scaffolding in auditory hair cells - a molecular tightrope walk enables lateral wall stiffness and flexibility.

Hearing research·2026
Same journal

Speech-in-noise recognition during hearing protector use: Human performance and acoustic prediction.

Hearing research·2026
Same journal

Estimation of hair cell loss from audiograms.

Hearing research·2026
Same journal

Cochlear size variation in a large-scale international multicentre cohort.

Hearing research·2026
Same journal

Estimation of minor-to-moderate conductive hearing loss with distortion-product otoacoustic emissions in humans.

Hearing research·2026
See all related articles

The GSTM1 gene may protect against hearing loss from noise and aging. This antioxidant enzyme

Area of Science:

  • Otoacoustic emissions and audiology research
  • Molecular biology and genetics
  • Occupational health and audiology

Background:

  • Cochlear hair cells are vulnerable to oxidative stress from noise and aging.
  • The specific metabolic factors influencing cochlear health are not fully understood.
  • Antioxidant enzymes, such as glutathione S-transferases, are present in the cochlea.

Purpose of the Study:

  • To investigate the role of metabolic factors, including vitamin E, vitamin C, and glutathione S-transferase (GSTM1 and GSTT1) gene polymorphisms, in human cochlear function.
  • To assess the impact of these factors on hearing in noise-exposed individuals.

Main Methods:

  • Audiometry and distortion product otoacoustic emissions were measured in 58 factory workers.
  • Blood levels of vitamin E and vitamin C were quantified.

Related Experiment Videos

  • Genotyping for GSTM1 and GSTT1 gene polymorphisms was performed.
  • Statistical analyses were conducted to identify predictive factors for hearing status.

    • Main Results:

    • Older age and higher cumulative noise exposure were associated with poorer hearing outcomes.
    • Higher vitamin E levels correlated with reduced hearing function, potentially due to age-related increases.
    • Individuals with the GSTM1 gene exhibited significantly better high-frequency otoacoustic emissions compared to GSTM1 null individuals.
    • The protective effect of GSTM1 remained significant after adjusting for age, race, sex, and noise exposure duration.
    • No significant protective effect was observed for the GSTT1 gene.

    Conclusions:

    • The glutathione S-transferase M1 (GSTM1) gene may play a protective role in maintaining human cochlear function against noise-induced or age-related damage.
    • Further research is needed to confirm the causal relationship between GSTM1 and hearing protection.
    • Metabolic factors, particularly genetic variations in antioxidant enzymes, warrant further investigation in the context of hearing health.