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Maintenance hemodialysis and circulating ionized magnesium.

Anita C Truttmann1, Rita Faraone, Rodo O Von Vigier

  • 1Inselspital, University of Berne, Switzerland.

Nephron
|October 10, 2002
PubMed
Summary
This summary is machine-generated.

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In end-stage kidney disease patients, hemodialysis lowers both total and ionized magnesium. The ionized magnesium fraction remains reduced after dialysis, indicating it does not correct this imbalance.

Area of Science:

  • Nephrology
  • Clinical Chemistry

Background:

  • Circulating magnesium exists in bound and biologically active free ionized forms.
  • Kidney disease alters the relationship between ionized and total magnesium.
  • Limited data exists on hemodialysis effects on magnesium in end-stage kidney disease.

Purpose of the Study:

  • To investigate the influence of hemodialysis on the relationship between ionized and total magnesium in end-stage kidney disease patients.

Main Methods:

  • Assessed plasma total and ionized magnesium and the ionized magnesium fraction before and after hemodialysis.
  • Included 46 end-stage kidney disease patients and 25 healthy controls.
  • Used a dialysate magnesium content of 0.75 mmol/l.

Main Results:

Related Experiment Videos

  • Plasma total and ionized magnesium significantly decreased in patients during hemodialysis.
  • The plasma ionized magnesium fraction was significantly lower in patients pre- and post-hemodialysis compared to controls.
  • Hemodialysis did not correct the reduced ionized magnesium fraction in end-stage kidney disease patients.

Conclusions:

  • End-stage kidney disease is associated with a tendency towards a reduced circulating ionized magnesium fraction.
  • Hemodialysis does not restore the ionized magnesium fraction to normal levels in these patients.