Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

The Movement of Organelles and Vesicles

The Movement of Organelles and Vesicles

In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...

Actin Polymerization and Cell Motility

Actin Polymerization and Cell Motility

Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.

Cytoskeletal Coordination in Cell Migration

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Simple Seasonal Switches in Food Web Composition Unveil the Complexity of an Arctic Predator-Prey System.

The American naturalist·2026

Same author

Evolutionary Dynamics at the Leading Edge of Biological Invasions.

Bulletin of mathematical biology·2026

Same author

Connectivity indices can predict population persistence in river networks: insights from a metapopulation model.

Landscape ecology·2026

Same author

How climate change can affect the dynamics of stage-structured seasonal breeders.

Journal of mathematical biology·2025

Same author

Traveling waves in a free boundary problem for the spread of ecosystem engineers.

Mathematical biosciences and engineering : MBE·2025

Same author

Evolution of dispersal in river networks.

Bulletin of mathematical biology·2024

Search research articles

Related Experiment Video

Updated: Jul 6, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

Modeling alignment and movement of animals and cells.

Frithjof Lutscher¹

¹Biomathematik, Auf der Morgenstelle 10, Universität Tübingen, Germany. flutscher@math.ualberta.ca

Journal of Mathematical Biology

|October 10, 2002

Summary

This study models collective animal behavior, like fish schooling, using reaction-transport equations. It shows how alignment influences movement and reduces predation risk in groups.

Area of Science:

Collective behavior
Mathematical modeling
Biophysics

Background:

Organized group movement, such as fish schooling and bird flocking, involves individuals aligning their speed and orientation with neighbors.
Alignment, the adaptation of orientation, occurs at various biological scales, from subcellular to whole organisms.
Understanding these collective dynamics is crucial for fields like ecology and systems biology.

Purpose of the Study:

To develop and analyze a mathematical model for collective alignment and movement in one and two dimensions.
To investigate the impact of schooling behavior on predation risk.
To compare the developed model with existing alignment models.

Main Methods:

Derivation of a model based on reaction-transport equations in one spatial dimension.

More Related Videos

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Related Experiment Videos

Last Updated: Jul 6, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Mathematical analysis to prove the existence of solutions and describe long-term system behavior.

Generalization of the model to two spatial dimensions for broader applicability.

Main Results:

The study demonstrates the existence of solutions for the alignment and movement model.
Long-time behavior of the system, including emergent group dynamics, is characterized.
A significant reduction in predation risk is observed due to schooling behavior.

Conclusions:

The reaction-transport model effectively captures key aspects of collective alignment and movement.
Alignment behavior, as modeled, provides a survival advantage by reducing predation risk.
The model offers a framework for studying collective phenomena across different biological scales.