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Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine
D A Baker1, H Shen, P W Kalivas
1Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston South Carolina 29425, USA. bakerda@musc.edu
Amino Acids
|October 10, 2002
Abstract:
Repeated administration of cocaine lowers the basal extracellular levels of glutamate in the nucleus accumbens as measured by microdialysis. The studies presented reveal that this long-term neuroadaptation elicited by repeated cocaine results from a decrease in the activity of cystine/glutamate exchange.