Related Experiment Video

Updated: Jul 22, 2026

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
09:37

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

Published on: December 2, 2014

[Left ventricular function of the coronary patient: relation between ventricular kinetic disorders and alterations of

P Besse, C Pruvot, A Choussat

    Archives Des Maladies Du Coeur Et Des Vaisseaux
    |February 1, 1975
    PubMed

    Insights

    Left ventricular contractility, assessed by Vmax and VECmax, is crucial for coronary heart disease prognosis. Reduced ejection fraction and increased hypokinetic areas indicate potential cardiac failure and guide treatment decisions.

    Area of Science:

    • Cardiology
    • Cardiac Physiology

    Context:

    • Assesses left ventricular kinetics in 29 coronary patients using biplane angiocardiography.
    • Evaluates contractility via Vmax and VECmax indices during the isovolumetric phase.

    Purpose:

    • To investigate the relationship between hypokinetic areas, ejection fraction, and cardiac function in coronary artery disease patients.
    • To determine the prognostic and operability value of Vmax, ejection fraction, and hypokinetic areas.

    Summary:

    • A strong correlation exists between hypokinetic area size and decreased ejection fraction (SV/LSV).
    • Ejection fraction below 0.40 and hypokinetic areas exceeding 20% of the endocardial surface indicate manifest cardiac failure.
    • Myocardial hypertrophy adjacent to fibrous scars can compensate for ventricular dysfunction, but diminished contractility may still occur.

    Impact:

    • Vmax, ejection fraction, and hypokinetic areas serve as excellent prognostic and operability criteria.
    • Findings aid in predicting patient outcomes and guiding surgical interventions for coronary artery disease.

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