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[Apoptosis].

José Enrique Soria González1, Modesto Orea Solano

  • 1Departamento de Alergia e Inmunología Clínica, Servicio de Alergia e Inmunología Clínica, Hospital Regional Lic. Adolfo López Mateos, ISSSTE, Av. Universidad 1321, Col. Florida, 01414, México, DF.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|October 11, 2002
PubMed
Summary

Apoptosis, or programmed cellular death, is crucial for development and homeostasis. Dysregulation of apoptosis contributes to various diseases, including cancer and neurodegenerative disorders.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Pathology

Context:

  • Apoptosis, identified 40 years ago, is programmed cellular death with minimal tissue reaction.
  • Morphologically, it involves cell shrinkage, nuclear condensation, and fragmentation into apoptotic bodies for phagocytosis.

Purpose:

  • To outline apoptosis signaling pathways, involved genes, and receptors.
  • To discuss the role of apoptosis in disease pathogenesis and its implications.

Summary:

  • Focuses on caspase-mediated apoptosis pathways, involving numerous genes and receptors like CD95 and TNF-R.
  • Highlights the biological significance of apoptosis in development, homeostasis, and disease.

Impact:

  • Excess or insufficient apoptosis is implicated in ischemic, neurodegenerative, autoimmune diseases, and cancer.
  • Understanding apoptosis mechanisms is key to developing treatments for a wide range of pathologies.

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