Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevating pain thresholds in humans using depolarizing prepulses.

Christopher J Poletto1, Clayton L Van Doren

  • 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44109, USA. polettoc@ninds.nih.gov

IEEE Transactions on Bio-Medical Engineering
|October 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coordinating voicing onset with articulation: a potential role for sensory cues in shaping phonological distinctions.

Phonetica·2010
Same author

Common neural substrates support speech and non-speech vocal tract gestures.

NeuroImage·2009
Same author

Sensory stimulation activates both motor and sensory components of the swallowing system.

NeuroImage·2008
Same author

The effect of surface electrical stimulation on vocal fold position.

The Laryngoscope·2007
Same author

Functional neuroanatomy of human voluntary cough and sniff production.

NeuroImage·2007
Same author

Human brain activation during phonation and exhalation: common volitional control for two upper airway functions.

NeuroImage·2007

Subthreshold electrical prepulses (PP) significantly increase pain thresholds for electrocutaneous stimulation. This method reduces the likelihood of pain from small electrodes, enhancing applications in virtual reality and neuroprosthetics.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Human-Computer Interaction

Background:

  • Electrocutaneous stimulation via small electrodes is crucial for virtual reality, sensory substitution, and augmentation.
  • Pain perception during stimulation limits the practical use of electrode arrays.

Purpose of the Study:

  • To investigate a method for increasing the pain threshold of electrocutaneous stimulation using small electrodes.
  • To test the efficacy of subthreshold depolarizing prepulses (PP) in mitigating pain.

Main Methods:

  • Psychophysical methods were employed to measure pain perception.
  • Stimulus pulses (SP) were delivered alone and preceded by PPs of varying amplitudes (2-10 dB lower than SP).

Main Results:

Related Experiment Videos

  • Prepulses (PP) significantly elevated the pain threshold for electrocutaneous stimulation (p < .0001).
  • A significant dose-dependent effect was observed, with larger PPs yielding higher pain thresholds (p < .0001).

Conclusions:

  • This study demonstrates the first use of prepulses to raise electrical stimulation thresholds in humans.
  • Prepulses offer a promising strategy for reducing pain in electrocutaneous stimulation, potentially enabling wider use in neuroprosthetics and sensory augmentation.