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Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2

Atsushi Kumanogoh1, Satoko Marukawa, Kazuhiro Suzuki

  • 1Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

Nature
|October 11, 2002
PubMed
Summary

The semaphorin Sema4A protein, found on dendritic and B cells, boosts T cell activation and differentiation. Blocking Sema4A in mice prevents experimental autoimmune encephalomyelitis, revealing its role in immune responses.

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