Jove
Visualize
Contact Us

Related Experiment Videos

Is cancer really a 'local' cellular clonal disease?

M H Bronchud1

  • 1Hospital General of Granollers, Granollers, Barcelona, Spain. bronchud@abaforum.es

Medical Hypotheses
|October 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A European perspective on haematopoietic growth factors in haemato-oncology: report of an expert meeting of the EORTC.

European journal of cancer (Oxford, England : 1990)·1998
Same author

Filgrastim (r-metHuG-CSF): the first 10 years.

Blood·1996
Same author

Haemopoietic growth factors: uses and misuses.

European journal of cancer (Oxford, England : 1990)·1995
Same author

Recombinant human granulocyte colony-stimulating factor in the management of cancer patients: five years on.

Oncology·1994
Same author

The importance of dose: lymphomas as a model of chemosensitive malignancies.

European journal of cancer (Oxford, England : 1990)·1993
Same author

Haemopoietic growth factors: unravelling the secrets of blood formation.

European journal of cancer (Oxford, England : 1990)·1991
Same journal

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Medical hypotheses·2026
Same journal

Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

Medical hypotheses·2025
Same journal

The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

Medical hypotheses·2025
Same journal

Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

Medical hypotheses·2025
Same journal

How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Medical hypotheses·2024
Same journal

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Cancer develops through a multistep process requiring multiple genetic mutations. Understanding background carcinogenesis may enable early cancer risk detection and targeted therapies.

Area of Science:

  • Oncology
  • Genetics
  • Cell Biology

Background:

  • Cancer arises from a complex multistep process, not just single gene alterations.
  • Accumulating multiple critical mutations requires specific conditions, including cell proliferation and selection pressures.
  • Cellular protective mechanisms exist to prevent carcinogenesis.

Purpose of the Study:

  • To propose a unified model integrating 'field cancerization' and 'multistep carcinogenesis'.
  • To highlight the importance of background genetic alterations in cancer development.
  • To explore the potential for early cancer risk detection and therapeutic intervention.

Main Methods:

  • Theoretical modeling integrating existing cancer theories.
  • Discussion of mathematical probabilities of mutation accumulation.

Related Experiment Videos

  • Emphasis on the need for sensitive molecular technologies to test hypotheses.

    • Main Results:

    • A unified 'multistep field cancerization' model is proposed.
    • The likelihood of cancer development is influenced by the background level of genetic alterations in surrounding tissues.
    • A high background of genetic alterations increases the probability of accumulating necessary mutations.

    Conclusions:

    • The 'multistep field cancerization' model offers a comprehensive framework for understanding cancer development.
    • Measuring 'background carcinogenesis' could lead to early cancer risk assessment.
    • This approach may pave the way for novel therapeutic strategies to prevent or delay cancer progression.