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BCR-ABL insufficiency for the transformation of human stem cells into CML

G T Matioli1

  • 1USC Medical School, Los Angeles, California 90033, USA.

Medical Hypotheses
|October 12, 2002
PubMed

Abstract:

On the basis of numerical and kinetic data, the paper argues against the tenet that BCR-Abl is sufficient for transforming into Chronic Myelogenous leukemia a human hemopoietic stem cell, regardless of degree of pluripotency.

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