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Serum leptin levels of menopausal women before and after hormone replacement therapy
Wen-Ling Li1, Xin-Yu Guo, Jin-Yu Zhang
1Department of Gynecology and Obstetrics, General Hospital of Guangzhou Command, Guangzhou 510010, China.
Objective:
To measure serum leptin levels of menopausal women before and after hormone replacement therapy, and to evaluate the action of hormone replacement therapy in regulating serum leptin levels.
Methods:
Serum leptin levels of 27 menopausal women were measured before and after hormone replacement therapy by double-antibody enzyme-linked immunosorbent assay (ELISA) and compared with those measured in 35 women with regular menstrual cycle.
Results:
Compared with normal control (17.11+/-1.24 ng/ml), menopausal women showed significant higher mean serum leptin levels (20.75+/-2.80 ng/ml, P<0.01). After hormone replacement therapy for 6 months, serum leptin levels in these women declined to (17.46+/-1.71 ng/ml), similar to the leptin levels of normal control (P>0.05).
Conclusion:
Serum leptin levels are significantly higher in menopausal women than in women with regular menstrual cycle, and can be down-regulated by hormone replacement therapy. It is suggested that serum leptin levels might be used as an indicator to evaluate the effect of hormone replacement therapy in menopausal women.
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