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Hepatic resection for colorectal liver metastases: prospective study
1Centre for the Study of Liver Disease and Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi
|October 12, 2002
Summary
Hepatic resection for colorectal liver metastases is a safe procedure with acceptable outcomes. High preoperative carcinoembryonic antigen and positive resection margins negatively impact survival.
Area of Science:
- Hepatobiliary surgery
- Surgical oncology
- Gastroenterology
Background:
- Colorectal liver metastases (CLM) are common.
- Hepatic resection offers a potential cure.
- Long-term outcomes require evaluation.
Purpose of the Study:
- To assess operative and long-term survival after hepatic resection for CLM.
- To identify factors influencing survival.
Main Methods:
- Prospective study over 11 years in a Hong Kong tertiary referral center.
- 72 patients underwent hepatic resection for CLM.
- Data collected on clinical, pathological, and outcome variables.
Main Results:
- Operative morbidity was 19%, hospital mortality 4%.
- 5-year survival rate was 31.9%.
- High CEA and positive resection margins were independent risk factors for poor survival.
Conclusions:
- Hepatic resection for CLM is safe with acceptable morbidity and mortality.
- Satisfactory long-term survival can be achieved.
- Preoperative CEA and margin status are critical prognostic indicators.