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Related Experiment Videos

Schistosome glycoconjugates in host-parasite interplay.

C H Hokke1, A M Deelder

  • 1Department of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. c.h.hokke@lumc.nl

Glycoconjugate Journal
|October 12, 2002
PubMed
Summary
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Schistosomes, parasites causing schistosomiasis (bilharzia), evade host immunity using unique glycans. This review details schistosome glycan structures and their crucial roles in parasite survival and disease.

Area of Science:

  • Parasitology
  • Immunology
  • Glycobiology

Background:

  • Schistosomiasis is a major parasitic disease affecting 200 million people globally.
  • Schistosomes reside in blood vessels and manipulate host immune responses for survival.
  • Glycoconjugates on schistosomes are key to their immune evasion strategies.

Purpose of the Study:

  • To review structural data on schistosome glycans.
  • To explore the role of these glycans in the immunology of schistosomiasis.
  • To provide insights into schistosome glycobiology and host-parasite interactions.

Main Methods:

  • Literature review of structural data on schistosome glycans.
  • Analysis of immunological studies concerning schistosome glycans.
  • Synthesis of current knowledge on glycobiology and immunology in schistosomiasis.

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Main Results:

  • Detailed structural information on schistosome glycans is becoming available.
  • Schistosome glycans are critical for evading host immune responses.
  • Host immune responses target specific glycan structures during infection.

Conclusions:

  • Schistosome glycans are central to the parasite's survival and pathogenesis.
  • Understanding schistosome glycobiology is vital for developing new schistosomiasis treatments.
  • Further research into glycan-mediated immune modulation is warranted.