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Platelet scintigraphy in the diagnosis of arteriosclerosis obliterans
Yoshihisa Morimoto1, Takaki Sugimoto, Masayoshi Okada
1Department of Surgery, Division II, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Insights
Platelet scintigraphy using 111In-oxine labeled platelets shows promise for assessing arteriosclerotic activity in arteriosclerosis obliterans (ASO). Efficacy is higher in patients not on antithrombotic agents.
Area of Science:
- Nuclear Medicine
- Vascular Biology
- Radiopharmacology
Background:
- Arteriosclerosis obliterans (ASO) is a significant vascular disease.
- Accurate assessment of arteriosclerotic activity is crucial for patient management.
Purpose of the Study:
- To evaluate the efficacy of platelet scintigraphy using autologous platelets labeled with 111In-oxine.
- To assess the degree of arteriosclerotic activity in patients with ASO.
Main Methods:
- Thirty-three patients with ASO were enrolled.
- Platelet scintigraphy results were compared with contrast angiography findings.
- The influence of antiplatelet/anticoagulant drugs was considered.
Main Results:
- Platelet accumulation was observed at 45% of angiographically identified atherosclerotic lesions.
- Scintigraphy detected lesions with less than 50% stenosis less frequently than more severe lesions.
- True-positive scintigraphic results were significantly higher in patients not taking antithrombotic agents (70% vs. 32%).
Conclusions:
- 111In-oxine-labeled platelet imaging may be valuable for evaluating pathophysiologic characteristics of atherosclerotic lesions in ASO.
- The presence of antithrombotic agents can affect scintigraphy results.
Purpose:
We evaluated the efficacy of platelet scintigraphy using autologous platelets labeled with 111In-oxine, to assess the degree of arteriosclerotic activity in arteriosclerosis obliterans (ASO).
Methods:
Thirty-three patients with clinical signs of ASO, seen between January 1996 and August 1999, were enrolled in this study. Scintigraphic imaging results were compared with the findings of contrast angiography in 26 patients, 17 of whom were taking antiplatelet and/or anticoagulant drugs during the platelet imaging study.
Results:
Angiography demonstrated atherosclerotic lesions at 38 sites from the abdominal aorta to the popliteal arteries in 23 patients. There was an accumulation of platelets at 17 of these sites (45%) and at 6 other sites without definite angiographic abnormalities. Lesions that resulted in less than 50% stenosis were detected slightly, but not significantly, less often than lesions with higher degrees of stenosis and occlusion (50% vs 30%, P = 0.73). The frequency of true-positive scintigraphic results was statistically higher in patients not taking antithrombotic agents than in those taking antithrombotic agents (70% vs 32%, P = 0.02).
Conclusions:
Our results suggest that imaging with 111In-oxine-labeled platelets may be useful for evaluating the pathophysiologic characteristics of atherosclerotic lesions in patients with ASO.