Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Demyelinating pseudotumor.

Irma E Erana-Rojas1, Alvaro Barboza-Quintana, Alberto G Ayala

  • 1Department of Pathology, Hospital San Jose-Tec de Monterrey, Monterrey, Nuevo Leon, Mexico.

Annals of Diagnostic Pathology
|October 12, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Final results of the Choroid Plexus Tumor Study CPT-SIOP-2000.

Journal of neuro-oncology·2025
Same author

Retraction Note: Suppression of glioma invasion and growth by adenovirus-mediated delivery of a bicistronic construct containing antisense uPAR and sense p16 gene sequences.

Oncogene·2025
Same author

Adoption of the T2-FLAIR Mismatch Sign among Radiologists: How Well Are We Doing?

AJNR. American journal of neuroradiology·2025
Same author

Retraction Note: Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.

Oncogene·2025
Same author

Mesenchymal Stem Cells and Fibroblasts Contribute to Microvascular Proliferation in Glioblastoma and are Correlated with Immunosuppression and Poor Outcome.

Cancer immunology research·2025
Same author

Response of treatment-naive brain metastases to stereotactic radiosurgery.

Nature communications·2024
Same journal

Development and clinical application of a histopathology-based pathological scoring system for IgG4-related disease.

Annals of diagnostic pathology·2026
Same journal

Improved prostate cancer grading by incorporating Gleason pattern quantification, invasive cribriform and intraductal carcinoma in the new QUICC-score.

Annals of diagnostic pathology·2026
Same journal

The long-term postoperative course of an intraosseous spindle cell hemangioma of the calcaneus.

Annals of diagnostic pathology·2026
Same journal

Myoepithelioma-like tumor of the vulvar region shows a quiet genome and heterogeneous detectable mechanisms of SMARCB1 inactivation: Integrated analysis of two cases and review of the literature.

Annals of diagnostic pathology·2026
Same journal

Re-evaluation of "Peptic" duodenitis: A review of 622 consecutive duodenal biopsies.

Annals of diagnostic pathology·2026
Same journal

Unusual morphologic features in molecularly defined high-grade sarcomas of the uterus.

Annals of diagnostic pathology·2026
See all related articles

Demyelinating disease can mimic brain tumors, presenting diagnostic challenges. Recognizing specific histological features like Creutzfeldt astrocytes and macrophage infiltration is crucial to avoid misdiagnosis of these demyelinating pseudotumors.

Area of Science:

  • Neuropathology
  • Neuroradiology
  • Diagnostic Pathology

Background:

  • Solitary contrast-enhancing brain masses often suggest neoplasia, posing diagnostic challenges.
  • Demyelinating diseases can present as space-occupying lesions mimicking tumors.

Observation:

  • Two female patients (23 and 37 years) presented with solitary, ring-enhancing parietal lesions on MRI.
  • Initial frozen sections suggested glial neoplasms due to hypercellularity and mitotic figures.

Findings:

  • Permanent sections revealed Creutzfeldt astrocytes and granular mitoses, indicative of demyelination.
  • Immunohistochemistry confirmed macrophage infiltration (HAM-56, CD68) and reactive astrocytosis (GFAP).
  • Special stains demonstrated focal myelin loss with relative axonal preservation, confirming demyelinating pseudotumors.

Related Experiment Videos

Implications:

  • Awareness of demyelinating pseudotumors mimicking tumors is vital for accurate diagnosis.
  • Characteristic histological features and immunohistochemistry aid in differentiating from diffuse gliomas.
  • Correct diagnosis prevents inappropriate and harmful therapies for demyelinating lesions.