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Localised Ewing sarcoma/PNET of bone--prognostic factors and international data comparison
R Derek Jenkin1, Ibrahim Al-Fawaz, Mohammed Al-Shabanah
1Department of Oncology, Section of Radiation Oncology, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh, Saudi Arabia 11211. derek.jenkin@sci.kfshrc.edu.sa
Medical and Pediatric Oncology
|October 12, 2002
Summary
Survival rates for localized bone Ewing Sarcoma/Pediatric Neuroectodermal Tumor (PNET) improved significantly over time. Favorable tumor sites and smaller volumes correlated with better outcomes, approaching international benchmarks.
Area of Science:
- Pediatric Oncology
- Bone Tumors
- Sarcoma Research
Background:
- Assessing prognostic factors in localized Ewing Sarcoma/PNET bone tumors in Saudi Arabia.
- Comparing outcomes with developed healthcare systems.
Purpose of the Study:
- To evaluate the impact of prognostic factors on localized Ewing Sarcoma/PNET bone tumor outcomes.
- To compare Saudi Arabian patient results with international data.
Main Methods:
- Retrospective analysis of 163 patients (1975-1998) treated with radical intent.
- Standard chemotherapy with surgery and/or radiation therapy.
- Tumor size data analyzed for patients from 1994-1998.
Main Results:
- Three-year survival improved significantly over time (45% to 63%).
- Favorable factors: younger age, distal extremity/skull sites, smaller tumor volume (<200 ml).
- High survival (80-82%) observed for small tumors/favorable sites (1994-1998).
Conclusions:
- Overall survival for localized bone Ewing Sarcoma/PNET has progressively improved.
- Outcomes for small tumors/favorable sites match top international results.
- A refined staging system is needed for accurate international comparisons.