A reference database for tumor-related genes co-expressed with interleukin-8 using genome-scale in silico analysis
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Published on: October 11, 2019
Lawrence Benbow1, Lynn Wang, Maureen Laverty
1Discovery Technology Department, Schering-Plough Research Institute, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, USA. lawrence.benbow@spcorp.com
Background:
The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8.
Results:
IL-8 is represented in 53 dbEST cDNA libraries. We calculated the frequency of occurrence of all the genes represented in these cDNA libraries, and ranked the candidates based on a Z-score. Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries.
Conclusions:
This method generated a reference database for genes co-expressed with IL-8 and could facilitate further characterization of functional association among genes.
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