Related Experiment Videos
The p47phox PX domain: two heads are better than one!
1Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Structure (London, England : 1993)
|October 16, 2002
Abstract:
The recent X-ray structure of the PX domain of p47phox, a critical subunit of the NADPH oxidase, unexpectedly revealed the presence of two distinct lipid binding pockets within this single modular domain. This unusual feature allows the p47phox PX domain to integrate signal transduction events emerging from two different lipid signaling pathways.