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Related Experiment Videos

Repeated nicotine injections decrease operant ethanol self-administration.

Amanda L Sharpe1, Herman H Samson

  • 1Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA. sharpea@ohsu.edu

Alcohol (Fayetteville, N.Y.)
|October 16, 2002
PubMed
Summary
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Nicotine administration reduced ethanol intake and appetitive behaviors in rats. This study investigated nicotine

Area of Science:

  • Neuroscience and behavioral science
  • Pharmacology
  • Addiction research

Background:

  • Nicotine and alcohol are widely used drugs in the U.S.
  • The reasons for co-use (pharmacological, environmental, or both) are not fully understood.
  • Previous animal studies suggest nicotine influences ethanol consumption, but its specific effects on the different phases of self-administration are unclear.

Purpose of the Study:

  • To investigate the effect of repeated nicotine treatment on the appetitive and consummatory phases of ethanol self-administration in a rat model.
  • To determine how different doses of nicotine impact ethanol intake and the behaviors preceding it.

Main Methods:

  • Long-Evans rats were administered nicotine (0, 0.35, or 0.7 mg/kg) 30 minutes before daily operant sessions.

Related Experiment Videos

  • Rats self-administered 10% ethanol in a sipper-tube model.
  • Appetitive (lever pressing) and consummatory (ethanol intake) phases were measured.

    • Main Results:

    • Ethanol intake (consummatory phase) was reduced at both tested doses of nicotine.
    • Lever pressing (appetitive phase) decreased significantly after the high dose of nicotine.
    • These findings indicate nicotine affects ethanol self-administration, specifically reducing drinking behavior in this model.

    Conclusions:

    • Nicotine administration can alter ethanol self-administration in rats.
    • The study observed a reduction in ethanol consumption, contrasting with some previous findings.
    • Further research is needed to elucidate the mechanisms underlying nicotine's effect on alcohol appetitive and consummatory behaviors.