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Related Experiment Videos

[Normal values for Lactate- and Glutamate dehydrogenate by new optimized methods (author's transl)].

S Veit, F Sitzmann, H Prestele

    Klinische Padiatrie
    |May 1, 1975
    PubMed
    Summary

    Serum enzyme activities of Lactate dehydrogenase (LDH), Hydroxybutyrate dehydrogenase (HBDH), Glutamate dehydrogenase (GlDH), and Leucine aryl peptidase (LAP) vary with age in children. Newborns and infants show higher levels, stabilizing after age two.

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    Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid regimens for the treatment of active lupus nephritis.

    Lupus·2011

    Area of Science:

    • Biochemistry
    • Clinical enzymology
    • Pediatric diagnostics

    Context:

    • Establishing age-specific normal ranges for serum enzymes is crucial for accurate pediatric diagnosis.
    • Previous studies may lack comprehensive data across diverse pediatric age groups.
    • Optimized assay methods ensure reliable enzyme activity measurements.

    Purpose:

    • To determine age-dependent normal serum enzyme activities for LDH, HBDH, GlDH, and LAP in a large pediatric cohort.
    • To analyze the distribution patterns and physiological variations of these enzymes across different age groups.
    • To evaluate the diagnostic utility and specificity of these enzymes in children.

    Summary:

    • Serum enzyme activities of LDH, HBDH, GlDH, and LAP were measured in 934 children using optimized methods.

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  • Enzyme levels exhibited age-dependent variations, with significantly higher activities in newborns and infants compared to older children.
  • Log-normal distribution characterized enzyme values, except in newborns and young sucklings. Activities stabilized after two years.
  • GlDH demonstrated good diagnostic selectivity, while LDH and HBDH were less specific. No sex-based differences were observed.

    • Impact:

    • Provides essential reference ranges for pediatric serum enzyme analysis.
    • Aids in the interpretation of enzyme activity results in clinical settings.
    • Highlights the importance of age-matching for accurate diagnostic conclusions in pediatric patients.