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The first human case of hepatic dirofilariasis.

Min Kyung Kim1, Chul Hwan Kim, Beom Woo Yeom

  • 1Department of Pathology, Guro Hospital, Korea University College of Medicine, Seoul, Korea.

Journal of Korean Medical Science
|October 16, 2002
PubMed
Summary

This study reports the first case of hepatic dirofilariasis in a human, diagnosed surgically. The infection involved a liver nodule caused by the nematode Dirofilaria immitis.

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Area of Science:

  • Veterinary Parasitology
  • Human Pathology
  • Hepatology

Background:

  • Dirofilariasis, typically affecting canids, can rarely infect humans.
  • Human infections usually manifest as pulmonary or subcutaneous nodules.
  • Unusual sites of human dirofilariasis include large vessels and the peritoneal cavity.

Observation:

  • A 39-year-old man presented with an incidental hepatic nodule.
  • Surgical resection revealed a granulomatous lesion with central necrosis.
  • Histopathology identified numerous cross-sections of a degenerated nematode consistent with Dirofilaria immitis.

Findings:

  • Microscopic examination showed nematode structures with characteristic cuticle and internal organs.
  • The parasite measured 30-80 micro m in diameter.

Related Experiment Videos

  • Enzyme-linked immunosorbent assay confirmed positive antibody response to Dirofilaria immitis antigen.

    • Implications:

    • This case represents the first documented instance of human hepatic dirofilariasis.
    • Highlights the potential for Dirofilaria immitis to cause infection in unusual human organs.
    • Underscores the importance of considering parasitic infections in hepatic lesions, even in asymptomatic individuals.