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Extracorporeal membrane oxygenation in piglets using a polymerized bovine hemoglobin-based oxygen-carrying solution
Gregory B York1, Robert J DiGeronimo, Bernard J Wilson
1Department of General Surgery, Wilford Hall Medical Center, Lackland AFB, TX, USA.
Journal of Pediatric Surgery
|October 16, 2002
Summary
Polymerized bovine hemoglobin (HBOC-201) effectively substitutes for blood in porcine extracorporeal membrane oxygenation (ECMO), maintaining hemodynamics and oxygen capacity while reducing volume needs.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Hemorrhage Management
Background:
- Extracorporeal membrane oxygenation (ECMO) requires blood products for priming, posing challenges.
- Hemoglobin-based oxygen carriers (HBOCs) are investigated as blood substitutes.
- HBOC-201, a polymerized bovine hemoglobin solution, is a potential candidate.
Purpose of the Study:
- To evaluate HBOC-201 as a blood substitute in a porcine ECMO model.
- To compare HBOC-201-primed ECMO with traditional blood-primed ECMO.
- To assess hemodynamic stability and oxygen-carrying capacity.
Main Methods:
- Ten piglets underwent venoarterial ECMO.
- Four animals received blood-primed ECMO; six received HBOC-201-primed ECMO.
- Hemodynamic, blood gas, and laboratory parameters were monitored for 6 hours.
Main Results:
- All animals survived the 6-hour ECMO procedure.
- No significant differences in heart rate, mean arterial pressure, urine output, or lactate levels.
- HBOC-201 group required significantly less postpriming volume and had lower hematocrit.
Conclusions:
- HBOC-201-primed ECMO demonstrated comparable hemodynamics and oxygen transport to blood-primed ECMO.
- HBOC-201 significantly reduced the need for additional priming volume.
- HBOC-201 shows promise as a blood substitute in ECMO, warranting further research.