Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functions of AP1 (Fos/Jun) in bone development.

E F Wagner1

  • 1Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria. wagner@nt.imp.univie.ac.at

Annals of the Rheumatic Diseases
|October 16, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C-phycocyanin to overcome the multidrug resistance phenotype in human erythroleukemias with or without interaction with ABC transporters.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2018
Same author

The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment.

Leukemia·2016
Same author

Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

Cell death & disease·2016
Same author

The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice.

Cell death and differentiation·2015
Same author

Loss of JUNB/AP-1 promotes invasive prostate cancer.

Cell death and differentiation·2014
Same author

Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression.

Cell death and differentiation·2014
Same journal

Genetic biomarkers of clinical manifestations in giant cell arteritis define distinct patient subgroups.

Annals of the rheumatic diseases·2026
Same journal

A data-driven, weighted flare score that accurately predicts organ damage in systemic lupus erythematosus.

Annals of the rheumatic diseases·2026
Same journal

PD-1 signalling restrains pathogenic T peripheral helper and effector CD4⁺ T cell functions in rheumatoid arthritis.

Annals of the rheumatic diseases·2026
Same journal

Remission of refractory lupus nephritis is temporally associated with antitumour therapy, including durvalumab for endometrial carcinoma.

Annals of the rheumatic diseases·2026
Same journal

Mapping inequalities in rheumatology care in Europe: the first edition of the EULAR RheumaFacts project.

Annals of the rheumatic diseases·2026
Same journal

Commentary on 'Assessing the performance of AI chatbots in answering patients common questions about low back pain'.

Annals of the rheumatic diseases·2026
See all related articles

Genetically modified mice reveal Activator Protein 1 (AP1) components regulate bone cell differentiation and development. Different AP1 proteins have distinct roles in embryonic and postnatal skeletal growth.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • The dimeric transcription factor complex AP1 plays a crucial role in cellular processes.
  • Understanding AP1's function is vital for comprehending skeletal development.

Purpose of the Study:

  • To elucidate the specific roles of AP1 components in skeletal development using genetically modified mice.
  • To gain molecular insights into the context-dependent functions of AP1 proteins.

Main Methods:

  • Utilized genetically modified mice (knockout models) to study AP1 component functions.
  • Analyzed the impact of AP1 components on bone cell differentiation, proliferation, and apoptosis.

Main Results:

  • Identified c-Fos as a key regulator of bone cell differentiation.

Related Experiment Videos

  • Demonstrated that c-Jun, JunB, and Fra-1 are essential for embryonic and/or postnatal development.
  • Began to understand cell-context dependent functions and downstream targets of AP1 proteins.

    • Conclusions:

    • AP1 components have distinct and essential roles in skeletal development.
    • Further research is needed to fully understand the molecular mechanisms of AP1 in bone biology.