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Published on: October 2, 2020

Is arterial hypertension an underlying factor in the increased serum Lp(a) levels in ESRD dialyzed patients?

Christina I Fytili1, Ploumis S Passadakis, Euaggelia G Progia

  • 1Biochemical Department, G.H.N. Papanikolaou Thessaloniki, Greece.

Renal Failure
|October 17, 2002
PubMed

Insights

Arterial hypertension significantly elevates Lipoprotein(a) [Lp(a)] levels in patients with end-stage renal disease (ESRD) undergoing dialysis. This finding highlights hypertension

Area of Science:

  • Nephrology
  • Cardiology
  • Lipidology

Background:

  • End-stage renal disease (ESRD) patients exhibit increased atherosclerotic changes.
  • Lipoprotein metabolism disorders are known contributors to atherosclerosis.
  • Arterial hypertension is an additional suspected factor in ESRD-related atherosclerosis.

Purpose of the Study:

  • To investigate the role of arterial hypertension in modulating serum lipid profiles, specifically Lipoprotein(a) [Lp(a)], in ESRD patients undergoing dialysis.
  • To compare Lp(a) levels in ESRD patients with and without hypertension, and with hyperlipidemic patients without renal failure.

Main Methods:

  • Serum lipid profiles, including total cholesterol, triglycerides, apolipoproteins (AI, AII, B, E), and Lp(a), were analyzed.
  • 109 ESRD patients (46 hemodialysis [HD], 63 continuous ambulatory peritoneal dialysis [CAPD]) were studied.
  • ESRD patients were categorized based on the presence of controlled arterial hypertension.
  • A control group of 45 hyperlipidemic patients without renal failure was included.

Main Results:

  • Lp(a) levels were significantly higher in both HD and CAPD patients compared to the hyperlipidemic control group.
  • Hypertensive ESRD patients (both HD and CAPD) exhibited statistically significantly higher Lp(a) levels than non-hypertensive ESRD patients.
  • No significant difference in Lp(a) levels was observed between hypertensive and non-hypertensive patients within the non-renal failure group.

Conclusions:

  • Arterial hypertension appears to be a significant contributing factor to elevated Lp(a) serum levels in ESRD patients undergoing dialysis (HD or CAPD).
  • These findings suggest that managing arterial hypertension may be crucial in mitigating cardiovascular risk associated with high Lp(a) in ESRD patients.

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