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Infantile autism in twins.

P E McQuaid

    The British Journal of Psychiatry : the Journal of Mental Science
    |December 1, 1975
    PubMed
    Summary

    This study presents male twins with early infantile autism (E.I.A.). It differentiates E.I.A. from infantile psychosis (I.P.) to guide prognosis and educational interventions, considering genetic and environmental factors.

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    Area of Science:

    • Pediatric Neurology
    • Genetics
    • Developmental Psychology

    Background:

    • Early Infantile Autism (E.I.A.) is a complex neurodevelopmental disorder.
    • Distinguishing E.I.A. from Infantile Psychosis (I.P.) is crucial for accurate diagnosis and prognosis.
    • Genetic factors are known to play a role in autism spectrum disorders.

    Purpose of the Study:

    • To present a case of monozygotic (MZ) male twins concordant for E.I.A.
    • To differentiate E.I.A. from I.P. for improved prognostic guidance.
    • To discuss the etiological relevance of prenatal and perinatal factors in E.I.A.

    Main Methods:

    • Case study of MZ male twins.
    • Clinical observation and diagnostic assessment.
    • Review of etiological factors, including prenatal and delivery history.

    Main Results:

    • The twins were concordant for early infantile autism.
    • A clear distinction was made between E.I.A. and I.P. with mental retardation.
    • Abnormal ante-natal history and delivery status were noted as relevant factors.

    Conclusions:

    • Differentiating E.I.A. from I.P. is vital for tailoring social training and educational strategies.
    • While genetic predisposition is important, environmental factors like abnormal ante-natal and delivery conditions can influence E.I.A. development.
    • Further research into the interplay of genetic and environmental factors in E.I.A. is warranted.

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