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Circulating hematopoietic progenitor cells in runners.

Maria R Bonsignore1, Giuseppe Morici, Alessandra Santoro

  • 1Institute of Respiratory Pathophysiology, National Research Council, 90146 Palermo, Italy. marisa@ifr.pa.cnr.it

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 17, 2002
PubMed
Summary

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Endurance running significantly increases hematopoietic progenitor cells (HPCs) in amateur runners, suggesting an adaptation to exercise-induced stress and inflammatory mediators that modulate bone marrow activity.

Area of Science:

  • Exercise Physiology
  • Hematology
  • Immunology

Background:

  • Endurance exercise stimulates the release of bone marrow mediators and growth factors.
  • Hematopoietic progenitor cells (HPCs) play a crucial role in blood cell formation and immune response.

Purpose of the Study:

  • To investigate the effect of endurance exercise on circulating hematopoietic progenitor cells (HPCs) in amateur runners.
  • To compare HPC levels in runners versus sedentary individuals and assess acute and post-exercise changes.

Main Methods:

  • Measured circulating HPCs (CD34(+) cells), plasma cortisol, IL-6, G-CSF, and flt3-ligand at rest and post-marathon (M) or half-marathon (HM).
  • Compared HPC counts and mediator levels between 16 amateur runners and 9 sedentary controls.
  • Analyzed acute and morning-postrace changes in HPCs and associated biomarkers.

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Main Results:

  • Runners exhibited three- to fourfold higher baseline circulating HPC counts than controls.
  • HPC counts were unaffected acutely post-M or HM but decreased the morning after.
  • IL-6 and G-CSF increased post-M more than post-HM; cortisol and flt3-ligand increased similarly postrace.

Conclusions:

  • Elevated baseline HPCs in runners likely represent an adaptation to recurrent exercise-induced stress and inflammatory mediator release.
  • Habitual running appears to modulate bone marrow activity, influencing hematopoietic progenitor cell circulation.