Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Zebrafish as a model for hearing and deafness.

Tanya T Whitfield1

  • 1Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Sheffield, S10 2TN, United Kingdom. t.whitfield@sheffield.ac.uk

Journal of Neurobiology
|October 17, 2002
PubMed
Summary

Zebrafish offer a powerful model for studying inner ear development and function. Genetic studies in zebrafish reveal key genes involved in hearing and balance, aiding research into human deafness disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of the semicircular canals and otolithic organs of the vertebrate inner ear.

Current topics in developmental biology·2025
Same author

Paired and solitary ionocytes in the zebrafish olfactory epithelium.

Chemical senses·2025
Same author

Paired and solitary ionocytes in the zebrafish olfactory epithelium.

bioRxiv : the preprint server for biology·2024
Same author

A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos.

Basic & clinical pharmacology & toxicology·2023
Same author

Enhancer trap lines with GFP driven by smad6b and frizzled1 regulatory sequences for the study of epithelial morphogenesis in the developing zebrafish inner ear.

Journal of anatomy·2023
Same author

Presence of chondroitin sulphate and requirement for heparan sulphate biosynthesis in the developing zebrafish inner ear.

Frontiers in cell and developmental biology·2022

Area of Science:

  • Developmental Biology
  • Genetics
  • Neuroscience

Background:

  • The zebrafish (Danio rerio) is a valuable vertebrate model organism.
  • It possesses rapid embryogenesis and accessible genetic tools.
  • The inner ear and lateral line systems are crucial for sensory perception.

Purpose of the Study:

  • To highlight the utility of zebrafish in inner ear research.
  • To identify genetic factors influencing inner ear development and function.
  • To explore zebrafish models for human hearing and balance disorders.

Main Methods:

  • Utilizing forward and reverse genetic approaches.
  • Analyzing mutations affecting the inner ear and lateral line.
  • Cloning and characterizing identified genes.

Related Experiment Videos

Main Results:

  • Isolation of numerous mutations impacting ear development and function.
  • Identification of several zebrafish mutations modeling human deafness.
  • Discovery of key signaling molecules and factors in otic placode induction.

Conclusions:

  • Zebrafish are instrumental for dissecting inner ear development and function.
  • Genetic studies in zebrafish provide insights into sensory system disorders.
  • The model is suitable for investigating the genetic basis of late-onset deafness and vestibular diseases.