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Related Experiment Videos

Evolution of collagens.

Jean-Yves Exposito1, Caroline Cluzel, Robert Garrone

  • 1Institut de Biologie et Chimie des Protéines, Université Claude Bernard, Lyon, France. jy.exposito@ibcp.fr

The Anatomical Record
|October 17, 2002
PubMed
Summary
This summary is machine-generated.

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Collagen, a key component of the extracellular matrix, evolved with multicellular animals (metazoa). Its triple helix structure facilitated the development of complex protein networks essential for structural integrity and evolution.

Area of Science:

  • Biochemistry
  • Evolutionary Biology
  • Developmental Biology

Background:

  • The extracellular matrix provides structural integrity and is vital for organismal development.
  • While extracellular matrix functions are conserved, compositions vary significantly across species.
  • Collagen is a ubiquitous component of metazoan extracellular matrices, found from sponges to humans.

Purpose of the Study:

  • To investigate the evolutionary history of collagens and collagen-like proteins.
  • To understand the role of collagen in the emergence and evolution of metazoa.
  • To explore the structural advantages of the collagen triple helix module.

Main Methods:

  • Comparative analysis of data from diploblastic, protostomic, and deuterostomic animals.

Related Experiment Videos

  • Tracing the evolutionary trajectory of collagens and related proteins.
  • Examining the structural properties of the collagen triple helix module.

    • Main Results:

    • Collagens and collagen-like proteins have a deep evolutionary history intertwined with metazoan origins.
    • The collagen triple helix emerged as a key module during metazoan radiation.
    • This module enables the formation of large, multimodular proteins resistant to proteases.

    Conclusions:

    • The evolution of collagen is fundamental to the development and diversification of multicellular animal life.
    • The collagen triple helix module is crucial for creating robust, supramolecular networks.
    • Understanding collagen evolution provides insights into metazoan structural organization and complexity.