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A heritable hyperlipemic rabbit.

T Kondo, Y Watanabe

Jikken Dobutsu. Experimental Animals

|July 1, 1975

Summary

This summary is machine-generated.

Researchers identified a rabbit mutant with significantly high cholesterol levels (HLR). This hypercholesterolemia is heritable and may serve as a model for human familial hyperlipemia.

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Area of Science:

Genetics
Biochemistry
Animal Models

Background:

Studying serous cholesterol in rabbits.
Discovery of a male mutant with remarkably high cholesterol levels (HLR).

Purpose of the Study:

Characterize the HLR mutant.
Investigate the heritability of hypercholesterolemia.
Determine if HLR can model human familial hyperlipemia.

Main Methods:

Serous chemical determinations of lipids and cholesterol.
Cross-breeding experiments (full-sib mating) to assess heritability.
Phenotypic analysis of offspring generations.

Main Results:

HLR mutant exhibited extremely high total lipids (3011 mg/dl), beta-lipoprotein (10.6 units), and total cholesterol (447 mg/dl).

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Hypercholesterolemia was persistent over two years.

Heritability analysis indicated a recessive, non-sex-linked gene.

One female offspring from full-sib mating showed similar hypercholesterolemia.

Conclusions:

The HLR rabbit is a valuable model for studying hypercholesterolemia.
This mutant may represent a model for human familial hyperlipemia Type II or III.
Further research can elucidate genetic mechanisms of hyperlipidemia.