Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amyloidosis in leprosy.

M Ozaki, M Furuta

    International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Systemic amyloidosis occurred more frequently in leprosy patients during the post-chemotherapy era in Japan. This condition was linked to younger patients and kidney disorders like pyelonephritis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    WJOG18524G: a single-arm phase II study evaluating bemarituzumab combined with ramucirumab and paclitaxel in fibroblast growth factor receptor 2b (FGFR2b)-positive advanced gastric or gastroesophageal junction cancer (RAINBIRD).

    ESMO gastrointestinal oncology·2026
    Same author

    An open-label phase Ib/II study of trastuzumab deruxtecan combined with nivolumab and CAPOX for HER2-low gastroesophageal adenocarcinoma.

    ESMO gastrointestinal oncology·2026
    Same author

    Lenvatinib for patients with previously treated advanced thymic carcinoma in real-world settings.

    ESMO open·2025
    Same author

    High-Resolution Detection of Translocation of Oral Bacteria to the Gut.

    Journal of dental research·2023
    Same author

    Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease.

    Journal of dental research·2019
    Same author

    Swallowing disorders and 1-year functional decline in community-dwelling older adults receiving home care.

    Journal of oral rehabilitation·2017
    Same journal

    Leprosy susceptibility-a matter of protein degradation? The role of proteasomes in infection and disease.

    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association·2006
    Same journal

    Leprosy and HIV infection (rarely the twain shall meet?).

    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association·2006
    Same journal

    Leprosy profile in Isfahan (A province of Iran).

    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association·2006
    Same journal

    The role of mycophenolate mofetil in the treatment of leprosy reactions.

    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association·2006
    Same journal

    Erythema nodosum leprosum necroticans in a child--an unusual manifestation.

    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association·2006
    Same journal

    Prevalence of leprosy in Agra District (U.P.) India from 2001 to 20031.

    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association·2006
    See all related articles

    Area of Science:

    • Medical Pathology
    • Nephrology
    • Immunology

    Background:

    • Systemic amyloidosis is a complication in leprosy patients.
    • Previous studies indicated lower incidences before chemotherapy in Japan.
    • Classification of amyloidosis remains complex, with varying criteria.

    Purpose of the Study:

    • To investigate the incidence and characteristics of systemic amyloidosis in leprosy patients in Japan.
    • To compare amyloidosis rates between pre- and post-chemotherapy periods.
    • To explore potential associations between amyloidosis, leprosy, and renal pathology.

    Main Methods:

    • Histopathologic examination of autopsy samples from leprosy patients.
    • Analysis of patient data from two Japanese leprosaria across different time periods (1955-1959 and 1962-1971).

    Related Experiment Videos

  • Correlation analysis between amyloidosis, patient age, leprosy type, and renal conditions.

    • Main Results:

    • Amyloid deposits were found in 46% of cases (Group A) and 15.4% (Group B), higher than pre-chemotherapy rates.
    • Amyloidosis patients were significantly younger than non-amyloidosis patients.
    • Pyelonephritis was common and correlated with amyloidosis incidence in Group B.

    Conclusions:

    • Systemic amyloidosis incidence in leprosy patients increased post-chemotherapy in Japan.
    • Renal disorders, particularly pyelonephritis, may play a role in the development of amyloidosis in leprosy.
    • Evidence suggests a possible resorptive process in human renal amyloidosis.