Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamin and endocytosis.

Sanja Sever1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Dana-Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA. sanja_sever@dfci.harvard.edu

Current Opinion in Cell Biology
|October 18, 2002
PubMed
Summary

Dynamin, crucial for endocytosis, may also function as a signaling GTPase. New research suggests its involvement in actin cytoskeleton, MAPK signaling, and apoptosis, expanding its known cellular roles.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of suPAR and related proteins in kidney, heart diseases, and diabetes.

The Journal of clinical investigation·2026
Same author

Recessive variants in the intergenic NOS1AP-C1orf226 locus cause monogenic kidney disease responsive to anti-proteinuric treatment.

Nature communications·2025
Same author

Treatment of Podocytopathies: Risky Business and Our Personal Journey.

Journal of the American Society of Nephrology : JASN·2024
Same author

Recessive variants in the intergenic <i>NOS1AP-C1orf226</i> locus cause monogenic kidney disease responsive to anti-proteinuric treatment.

medRxiv : the preprint server for health sciences·2024
Same author

The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease.

Science translational medicine·2023
Same author

The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5.

Kidney international·2023

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Dynamin is a GTPase vital for endocytosis.
  • Its precise mechanism of action is not fully understood.
  • Structural studies have advanced understanding of dynamin's function.

Purpose of the Study:

  • To elucidate the mechanism of dynamin's action.
  • To explore potential roles of dynamin beyond endocytosis.
  • To investigate dynamin's involvement in cellular signaling pathways.

Main Methods:

  • Structural analysis of dynamin's GTPase domain.
  • Examination of assembled dynamin structures.
  • Analysis of novel experimental data linking dynamin to other cellular processes.

Main Results:

  • Structural data provides insights into dynamin's mechanism.
  • Emerging evidence implicates dynamin in actin cytoskeleton regulation.
  • Dynamin shows potential roles in mitogen-activated protein kinase (MAPK) signaling and apoptosis.

Conclusions:

  • Dynamin's structural basis for its mode of action is increasingly clear.
  • Dynamin may function as a signaling GTPase.
  • Further research is warranted to explore dynamin's multifaceted roles in cellular signaling and function.

Related Experiment Videos