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Choroidal metastasis from medullary thyroid carcinoma in multiple endocrine neoplasia
Jerry A Shields1, Carol L Shields, Noel Perez
1Oncology Service Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Purpose:
To report choroidal metastasis from medullary thyroid carcinoma in a patient with multiple endocrine neoplasia (MEN) type 2b.
Design:
Interventional case report.
Methods:
Medullary thyroid carcinoma developed in a 20-year-old woman and led to the diagnosis of MEN 2b. She had mucosal neuromas on the lips and tongue and prominent corneal nerves in both eyes. Right choroidal metastasis developed when she was 36 years of age.
Results:
The eye was treated with irradiation, but 9 months later the patient died of widespread metastases.
Conclusions:
In patients with MEN type 2b, choroidal metastasis can develop from medullary thyroid carcinoma. Although fundus abnormalities typically do not occur with MEN 2b, choroidal metastasis from medullary thyroid carcinoma is a potential fundus finding.