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Systemic inflammatory response induced by dacron graft and modulation by antimicrobial agents: experimental study
Francisco S Lozano1, Francisco J García-Criado, Maria J Fresnadillo
1Surgical Investigations Unit, Department of Surgery, University Hospital, University of Salamanca, Spain. lozano@gugu.usal.es
The Journal of Surgical Research
|October 18, 2002
Summary
Antimicrobial agents, administered systemically or locally, effectively reduce bacterial translocation and systemic inflammatory response (SIR) following Dacron graft implantation in rats.
Area of Science:
- Biomedical Engineering
- Infectious Diseases
- Surgical Research
Background:
- Intraperitoneal implantation of collagen-coated Dacron grafts can trigger a systemic inflammatory response (SIR).
- Bacterial translocation is a potential complication following graft implantation.
Purpose of the Study:
- To evaluate the impact of various antimicrobial agents and administration routes on SIR induced by Dacron grafts.
- To assess the efficacy of antibiotics in mitigating bacterial translocation post-graft implantation.
Main Methods:
- Thirty-six rats underwent implantation of collagen-coated Dacron grafts.
- Groups received no antibiotic, systemic cefazolin, local gentamicin, or rifampicin soak.
- Bacterial translocation, cytokine levels, and inflammatory markers were analyzed after 72 hours.
Main Results:
- Graft implantation significantly increased bacterial translocation and SIR.
- Antibiotic treatment, irrespective of administration method, significantly reduced both bacterial translocation and SIR (P < 0.05).
Conclusions:
- Antibiotics effectively reduce bacterial translocation post-Dacron graft implantation.
- Antimicrobial agents modulate the systemic inflammatory response associated with intraperitoneal grafts.