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Polyanhydride degradation and erosion.

A Göpferich1, J Tessmar

  • 1Faculty of Pharmacy and Chemistry, Pharmaceutical Technology Unit, University of Regensburg, Universitätsstrasse 31, D-93053 Regensburg, Germany. achim.goepferich@chemie.uni-regensburg.de

Advanced Drug Delivery Reviews
|October 18, 2002
PubMed
Summary

This review surveys polyanhydride degradation and erosion, focusing on intensively studied polymers. Polyanhydrides primarily exhibit surface erosion, but transition to bulk erosion below a critical device size.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomaterials Engineering

Background:

  • Polyanhydrides are a significant class of degradable polymers with diverse applications.
  • Understanding their degradation and erosion mechanisms is crucial for material design and performance prediction.
  • Existing literature presents varied definitions for degradation and erosion, necessitating clarification.

Purpose of the Study:

  • To provide a comprehensive overview of polyanhydride degradation and erosion.
  • To clarify nomenclature by defining key terms like degradation and erosion.
  • To discuss the influence of polymer properties and geometry on these processes.

Main Methods:

  • Review of existing literature on polyanhydride degradation and erosion.

Related Experiment Videos

  • Analysis of properties of major polyanhydride classes.
  • Discussion of factors influencing drug release and stability within polyanhydrides.
  • Brief review of empirical and Monte-Carlo-based erosion models.

    • Main Results:

    • Polyanhydrides are generally surface eroding due to rapid degradation.
    • Device geometry significantly impacts degradation and erosion behavior.
    • Drug release control and drug stability are critical considerations for polyanhydride applications.
    • A transition from surface to bulk erosion occurs when device dimensions fall below a critical limit.

    Conclusions:

    • Polyanhydride degradation and erosion are complex processes influenced by material properties and device geometry.
    • Theoretical models aid in understanding the surface erosion phenomenon.
    • The transition to bulk erosion at smaller scales has implications for drug delivery device design.