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Related Experiment Videos

Poly(ortho esters): synthesis, characterization, properties and uses.

Jorge Heller1, John Barr, Steven Y Ng

  • 1A.P. Pharma, 123 Saginaw Drive, Redwood City, CA 94063, USA. jheller@appharma.com

Advanced Drug Delivery Reviews
|October 18, 2002
PubMed
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Poly(ortho esters) IV (POE IV) polymers offer versatile, stable drug delivery systems with tunable release rates. Their surface erosion and neutral pH properties enable controlled release for applications in pain, osteoarthritis, and ophthalmic diseases.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Poly(ortho esters) (POEs) have evolved over 30 years through four families (POE I-IV).
  • POE IV exhibits unique properties suitable for commercialization, including synthesis versatility and stability.
  • Surface erosion and neutral internal pH are key advantages for controlled drug release.

Purpose of the Study:

  • To highlight the advancements and commercialization potential of POE IV polymers.
  • To detail the synthesis versatility and tunable properties of POE IV.
  • To discuss the applications and ongoing clinical development of POE IV drug delivery systems.

Main Methods:

  • Synthesis of POE IV polymers with controlled mechanical, thermal, and erosion properties.

Related Experiment Videos

  • Fabrication of POE IV into solid (wafers, microspheres) and injectable semi-solid forms.
  • Evaluation of surface erosion, drug release kinetics, and pH stability.
  • Preparation and exploration of POE-poly(ethylene glycol) block copolymers.

    • Main Results:

    • POE IV demonstrates facile and reproducible synthesis with tunable erosion and drug release (days to months).
    • Polymers are stable at room temperature and exhibit surface erosion, ensuring controlled drug release and neutral internal pH.
    • Solid and injectable forms are under development, with GMP toxicology studies completed and Phase I trials initiated.
    • Block copolymers are being explored for drug delivery matrices and tumor-targeting micelles.

    Conclusions:

    • POE IV represents a highly promising class of polymers for advanced drug delivery applications.
    • The tunable properties and favorable erosion characteristics of POE IV support its commercialization.
    • Ongoing clinical trials and diverse application development underscore the therapeutic potential of POE IV.