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Propranolol inhibits hyphal development in Candida albicans
Carol A Baker1, Kevin Desrosiers, Joseph W Dolan
1Department of Microbiology & Immunology. Department of Stomatology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Antimicrobial Agents and Chemotherapy
|October 18, 2002
Abstract:
Propranolol was used to investigate the role of phosphatidic acid (PA) and diacylglycerol in the dimorphic transition in Candida albicans. Propranolol was able to inhibit the appearance of germ tubes without decreasing growth rate. Data suggest that inhibition of morphogenesis may be due to binding by propranolol of PA derived from PLD1 hydrolysis of phosphatidylcholine.