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TEM-103/IRT-28 beta-lactamase, a new TEM variant produced by Escherichia coli BM4511
Rodrigo Alonso1, Guy Gerbaud, Marc Galimand
1Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France.
Antimicrobial Agents and Chemotherapy
|October 18, 2002
Abstract:
Clinical isolate Escherichia coli BM4511 was resistant to broad-spectrum penicillins in the presence or in the absence of beta-lactamase inhibitors but remained susceptible to cephalosporins. Resistance was due to production of a new TEM-type beta-lactamase, designated TEM-103/IRT-28, characterized by the Arg(275)Leu substitution and encoded by the ca. 62-kb pIP845 conjugative plasmid of the IncI1 incompatibility group.