Related Experiment Video

Updated: Aug 10, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

KSHV- and EBV-associated germinotropic lymphoproliferative disorder

Ming-Qing Du1, Tim C Diss, Hongxiang Liu

  • 1Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK. m.du@ucl.ac.uk

Blood
|October 18, 2002
PubMed

Insights

We identified a new lymphoproliferative disorder associated with Kaposi sarcoma-associated herpesvirus (KSHV). This disorder, termed KSHV-associated germinotropic lymphoproliferative disorder, responds well to treatment.

Area of Science:

  • Oncology
  • Virology
  • Pathology

Background:

  • Kaposi sarcoma-associated herpesvirus (KSHV) is linked to primary effusion lymphoma (PEL), multicentric Castleman disease (MCD), and MCD-associated plasmablastic lymphoma.
  • A novel KSHV-associated lymphoproliferative disorder has been identified.

Purpose of the Study:

  • To describe the clinical, histological, and molecular features of a previously undescribed KSHV-associated lymphoproliferative disorder.
  • To propose a name for this new entity: KSHV-associated germinotropic lymphoproliferative disorder.

Main Methods:

  • Case series analysis of three patients with the novel disorder.
  • Histopathological examination including immunohistochemistry (CD20, CD27, CD79a, CD138, BCL6, CD10, kappa/lambda light chains).
  • Molecular analysis of immunoglobulin (Ig) gene rearrangement, KSHV, EBV, and viral interleukin-6 (vIL-6) expression.

Main Results:

  • The disorder presented as localized lymphadenopathy with a favorable response to chemotherapy or radiotherapy.
  • Histology revealed plasmablasts in germinal centers, negative for B-cell markers but positive for KSHV and EBV, often expressing vIL-6.
  • Molecular analysis showed polyclonal or oligoclonal Ig gene rearrangement with somatic mutation, suggesting germinal center B-cell origin.

Conclusions:

  • A distinct KSHV-associated lymphoproliferative disorder, characterized by germinotropic plasmablasts, has been identified.
  • The findings suggest an origin from germinal center B cells with evidence of somatic hypermutation.
  • This entity, named KSHV-associated germinotropic lymphoproliferative disorder, warrants recognition and further study.

More Related Videos

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

Related Concept Videos

Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...