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Related Experiment Videos

Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training.

Motoyuki Iemitsu1, Takashi Miyauchi, Seiji Maeda

  • 1Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan.

American Journal of Physiology. Heart and Circulatory Physiology
|October 18, 2002
PubMed
Summary

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Exercise training boosts fatty acid metabolism in aged hearts by upregulating peroxisome proliferator-activated receptor (PPAR)-alpha signaling. This enhances the heart

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Aging Research

Background:

  • Peroxisome proliferator-activated receptor (PPAR)-alpha regulates fatty acid metabolism.
  • Aging is associated with reduced cardiac fatty acid metabolic capacity.
  • The role of PPAR-alpha in exercise-induced improvements in aged hearts is unclear.

Purpose of the Study:

  • To investigate the effect of exercise training on PPAR-alpha signaling in aged rat hearts.
  • To determine if exercise training can reverse age-related declines in PPAR-alpha expression and activity.
  • To assess the impact on PPAR-alpha target genes involved in fatty acid metabolism.

Main Methods:

  • Comparison of sedentary young rats, sedentary aged rats, and swim-trained aged rats.

Related Experiment Videos

  • Quantification of myocardial PPAR-alpha mRNA and protein expression.
  • Assessment of PPAR-alpha DNA binding activity.
  • Measurement of mRNA expression and enzyme activity of PPAR-alpha target genes (HAD, CPT-I).

    • Main Results:

    • Sedentary aged rats exhibited significantly lower myocardial PPAR-alpha mRNA and protein levels compared to young rats.
    • Swim-trained aged rats showed significantly higher PPAR-alpha mRNA and protein levels than sedentary aged rats.
    • PPAR-alpha DNA binding activity, target gene expression (HAD, CPT-I), and HAD enzyme activity correlated with PPAR-alpha levels.

    Conclusions:

    • Exercise training effectively counteracts age-related downregulation of myocardial PPAR-alpha.
    • Improved PPAR-alpha signaling contributes to enhanced fatty acid metabolic enzyme activity in trained aged hearts.
    • Exercise is a viable strategy to improve cardiac metabolic function during aging.