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Updated: Aug 25, 2026

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
Infrarenal aortic dilatation less than 4 cm is not unusual in patients with aortoiliac occlusive disease
M Matsushita1, N Nishikimi, T Sakurai
1First Department of Surgery, Nagoya University, School of Medicine, Nagoya, Japan.
Insights
Atherosclerosis may contribute to aortic dilatation in patients with atherosclerotic aortoiliac occlusive disease (AIOD). Infrarenal aortic enlargement was linked to intraluminal thrombus and less calcification in AIOD patients.
Area of Science:
- Vascular Surgery
- Cardiovascular Medicine
- Radiology
Background:
- The link between atherosclerosis and abdominal aortic aneurysm (AAA) is debated.
- Atherosclerotic aortoiliac occlusive disease (AIOD) is a common manifestation of atherosclerosis.
- Infrarenal aortic aneurysm development requires further investigation.
Purpose of the Study:
- To assess the incidence of aortic dilatation in patients with AIOD.
- To investigate the role of aortic wall calcification and intraluminal thrombus in aneurysm development.
- To clarify the relationship between atherosclerosis and infrarenal aortic dilatation.
Main Methods:
- Retrospective study of 40 patients undergoing surgery for AIOD.
- Preoperative contrast-enhanced computed tomography (CT) used for evaluation.
- Measurements included infrarenal aortic diameter, calcification, and intraluminal thrombus.
Main Results:
- 40% of patients exhibited infrarenal aortic dilatation (> left renal vein level).
- 12.5% of patients had significant aortic enlargement (≥50%).
- Aortic diameter correlated negatively with calcification and positively with thrombus.
Conclusions:
- Aortic dilatation (<4 cm) is common in AIOD patients, suggesting an association with atherosclerosis.
- Atherosclerotic plaques with abundant thrombus and minimal calcification may predispose to aortic enlargement.
- Further research is needed to fully elucidate the pathogenesis of AAA in the context of AIOD.
Background:
The relationship between atherosclerosis and abdominal aortic aneurysm is now controversial. To better define the contribution of atherosclerosis to the development of aneurysm of the infrarenal aorta, we determined the incidence of aortic dilatation in patients undergoing arterial reconstruction for an atherosclerotic aortoiliac occlusive disease (AIOD). The role of aortic wall calcification and intraluminal thrombus was also determined.
Setting:
patients treated in a university hospital.
Subjects:
40 patients who underwent bifurcated graft bypass operation for AIOD without an abdominal aortic aneurysm =or>4 cm in size.
Measures:
Diameter, luminal calcification and intraluminal thrombus of the infrarenal aorta were evaluated using preoperative contrast enhancement computed tomography.
Results:
Sixteen patients (40%) had an infrarenal aorta larger than the aorta at the level of the left renal vein. Of these, 5 patients (12.5%) had a 50% enlargement or more. Infrarenal aortic diameter correlated negatively with the extent of calcification of the infrarenal aorta and positively with the amount of intraluminal thrombus.
Conclusions:
Infrarenal aortic dilatation less than 4 cm in size is not unusual in patients with AIOD, suggesting a possible relationship between aortic atherosclerosis and dilatation. An aorta with atherosclerotic plaque containing abundant thrombus and few calcifications may develop enlargement.
Related Concept Videos
Aortic Regurgitation I: Introduction
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
Aneurysm I: Introduction
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Aneurysm III: Interprofessional Care

