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[Stabilized NADH (ENADA) improves jet lag-induced cognitive performance deficit].

G D Birkmayer1, G G Kay, E Vürre

  • 1Labor Birkmayer & MEDINFO GmbH, Wien. office@birkmayer.com

Wiener Medizinische Wochenschrift (1946)
|October 19, 2002
PubMed
Summary

Reduced nicotinamide adenine dinucleotide (NADH) effectively combats jet lag symptoms. This study found NADH significantly improved cognitive function and reduced sleepiness after travel, offering a practical solution.

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Biochemistry

Background:

  • Current jet lag remedies like phototherapy and medication have limited effectiveness and practicality.
  • Jet lag negatively impacts cognitive functions such as attention, working memory, and visual processing, alongside increasing sleepiness.

Purpose of the Study:

  • To evaluate the efficacy of stabilized sublingual reduced nicotinamide adenine dinucleotide (NADH) as a jet lag countermeasure.
  • To determine if NADH can mitigate cognitive deficits and sleepiness associated with jet lag.

Main Methods:

  • A double-blind, placebo-controlled study involving 35 healthy subjects crossing a 3-hour time difference.
  • Participants received either 20 mg of sublingual stabilized NADH or a placebo upon arrival.
  • Cognitive function, mood, and sleepiness were assessed using computer-administered tests (including Cog Screen).

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Main Results:

  • Jet lag caused increased sleepiness in over half the participants and cognitive decline in approximately one third.
  • NADH group showed significantly better performance on 4 cognitive measures (P < .05) compared to placebo.
  • Subjects receiving NADH reported significantly less sleepiness than the placebo group.

Conclusions:

  • Stabilized sublingual NADH effectively reduces jet lag-induced cognitive impairments and sleepiness.
  • NADH is a practical and safe countermeasure for jet lag, with no observed adverse effects.
  • NADH's mechanism may involve increased ATP production and dopamine synthesis, counteracting jet lag effects.