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High sensitivity C-reactive protein: an emerging role in cardiovascular risk assessment

Laura R Benzaquen1, Harry Yu, Nader Rifai

  • 1Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA.

Critical Reviews in Clinical Laboratory Sciences
|October 19, 2002
PubMed

Insights

Chronic inflammation, particularly C-reactive protein (CRP), is linked to coronary heart disease (CHD) and atherosclerosis. High-sensitivity CRP assays aid in predicting cardiovascular events and understanding disease mechanisms.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Biology
  • Biomarker Research

Background:

  • Coronary heart disease (CHD) is a leading cause of mortality globally.
  • Conventional risk factor screening misses over 50% of individuals experiencing acute coronary syndromes.
  • Chronic inflammation is implicated in atherosclerosis development.

Purpose of the Study:

  • To review evidence linking inflammatory markers, especially C-reactive protein (CRP), to atherosclerosis and acute coronary syndromes.
  • To explore the mechanisms of risk associated with these inflammatory markers.
  • To assess the clinical utility of CRP in primary and secondary prevention settings.

Main Methods:

  • Literature review of studies investigating inflammatory markers and CHD.
  • Analysis of data on C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) assays.
  • Examination of research on the role of inflammation in atherogenesis.

Main Results:

  • Inflammatory markers, particularly CRP, are associated with the pathogenesis of atherosclerosis.
  • CRP serves as a prognostic indicator in acute coronary syndromes.
  • hs-CRP assays are valuable for assessing cardiovascular risk in primary prevention.

Conclusions:

  • Inflammation, as indicated by CRP, plays a significant role in cardiovascular disease.
  • CRP is a useful marker for predicting future coronary events and guiding clinical management.
  • Further research into inflammatory pathways can enhance CHD prevention strategies.

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