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Updated: Sep 28, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and preliminary pharmacological screening of novel imidazo[2,1-f]theophylline derivatives
Maciej Pawłowski1, Jacek Katlabi, Sławomir Jurczyk
1Department of Pharmaceutical Chemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Abstract:
The three different kinds of imidazo[2,1-f]theophylline derivatives were synthesized and tested for their CNS activity. A series of alkoxy-alkylamides and amino-alkylamides with basic function, derived from 8-benzyl-6,7-dihydroimidazo[2,1-f]theophylline-7-carboxylic acid showed stimulating influence on CNS as they increased the locomotor activity (compound 8 and 10) or enhanced amphetamine and apomorphine effects in mice (compounds 3, 4 and 9). Compounds 1, 5, 8-10 and 12 had anticonvulsant activity in the pentetrazole test; 12 with anellated imidazol-7-on ring (lactam structure) showed sedative properties and antiserotonin effects.
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