Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experience-dependent asymmetric variation in primate prefrontal morphology.

David M Lyons1, Hagop Afarian, Alan F Schatzberg

  • 1Department of Psychiatry and Behavioral Science, Psychiatry Neuroscience, Stanford University Medical School, 1201 Welch Road, MSLS Room P104, Mail Code 5485, CA 94305-5485, USA. dmlyons@stanford.edu

Behavioural Brain Research
|October 19, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-Dose Buprenorphine Following Ketamine Treatment for Suicidal Ideation in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.

The American journal of psychiatry·2026
Same author

General Anesthesia and Discrete Components of Ketamine Neurophysiology.

JAMA psychiatry·2026
Same author

Continuing Questions About Esketamine 5 Years After Approval: Response to Ahmed et al.

The American journal of psychiatry·2026
Same author

Stem cell therapy for ischemic stroke: neuroimaging approaches and evidence from a systematic review.

Frontiers in neurology·2026
Same author

Comment on Buse et al. Prevalence of Hypercortisolism in Difficult-to-Control Type 2 Diabetes. Diabetes Care 2025;48:2012-2020.

Diabetes care·2026
Same author

Stanford neuromodulation therapy for treatment-resistant depression: a randomized controlled trial confirming efficacy, and an EEG study providing insight into mechanism of action and a potentially predictive biomarker of efficacy.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026

Early life social experiences, specifically maternal availability, can impact brain development. This study found lasting differences in the right prefrontal cortex volume in adult monkeys, suggesting a link between early social experiences and emotional regulation brain structures.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Primatology

Background:

  • Theories suggest social experiences shape brain development, particularly prefrontal systems for emotional self-regulation.
  • Early maternal availability is known to influence emotional behavior, social tendencies, and stress responses.

Purpose of the Study:

  • To investigate experience-dependent effects on prefrontal gray and white matter volumes in adult monkeys.
  • To determine if early maternal availability alters adult prefrontal brain structure.

Main Methods:

  • Magnetic resonance imaging (MRI) was used to measure prefrontal gray and white matter volumes in 39 adult Saimiri sciureus monkeys.
  • These monkeys experienced varied early maternal availability conditions four years prior.

Related Experiment Videos

Main Results:

  • Significant differences were observed in right prefrontal cortex volumes, but not the left.
  • Experience-dependent, asymmetric variation was most pronounced in the ventral medial cortex.

Conclusions:

  • Early maternal availability influences the development of specific prefrontal brain regions in a sex- and hemisphere-asymmetric manner.
  • Further research is needed to clarify the direct and interactive roles of maternal availability and subsequent experiences on prefrontal substrates for emotional processing and stress sensitivity.