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Continuous bladder infusion methods for studying voiding function in the ambulatory mouse.

Annette Sessions1, Louis Eichel, Mulugeta Kassahun

  • 1Department of Urology, University of Rochester School of Medicine, Rochester, New York 14642-8668, USA.

Urology
|October 19, 2002
PubMed
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This study presents a new method for chronic bladder catheterization in mice, enabling repeated drug delivery and voiding pattern analysis in awake, mobile animals for up to five weeks.

Area of Science:

  • Urology
  • Animal Models
  • Pharmacology

Background:

  • Studying bladder function in mice typically requires invasive procedures or limits animal mobility.
  • Existing methods for chronic bladder catheterization in rodents are often short-term or hinder natural behavior.

Purpose of the Study:

  • To develop and validate a novel method for chronic bladder catheterization in mice.
  • To enable repeated intravesical drug delivery and continuous monitoring of voiding patterns in unrestrained mice.

Main Methods:

  • Implantation of a 3F polyurethane catheter in female mice under anesthesia.
  • Utilizing a tether and swivel system for protected, unencumbered mobility during continuous intravesical perfusion.
  • Monitoring voiding patterns using electronic balance technology.

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Main Results:

  • Consistent patent catheterization was achieved for at least 5 weeks.
  • Stable voiding patterns were observed within and across multiple weeks of continuous infusion.
  • Catheter patency was maintained, though some instances of mesh emergence and catheter withdrawal occurred.

Conclusions:

  • The developed method allows for consistent, patent chronic catheterization of the murine bladder for up to 5 weeks.
  • This technique, combined with specialized hardware, facilitates prolonged evaluation of micturition in awake, ambulatory mice.
  • The method supports repeated intravesical drug delivery and detailed voiding analysis.