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VEGF is an essential molecule for glomerular structuring.

Y Kitamoto¹, H Tokunaga, K Miyamoto

¹Third Department of Internal Medicine, Kumamoto University School of Medicine, Kumamoto 860 8556, Japan.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association

|October 19, 2002

Summary

Vascular endothelial growth factor (VEGF) is crucial for kidney development. Suppressing VEGF halts glomerular formation, indicating its essential role in forming kidney vasculature.

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Area of Science:

Nephrology
Developmental Biology
Vascular Biology

Background:

Glomerular development is analogous to angiogenesis and vasculogenesis.
Angiogenic cytokines are hypothesized to mediate glomerulogenesis.
Vascular Endothelial Growth Factor (VEGF) and its receptors are present in developing glomeruli.

Purpose of the Study:

To investigate the role of VEGF in glomerulogenesis.
To determine if VEGF is essential for the formation of glomerular capillaries.

Main Methods:

In vivo suppression of VEGF activity using a neutralizing antibody.
Analysis of glomerular development through vascular casting of renal vessels.

Main Results:

Related Experiment Videos

Suppression of VEGF activity severely impaired glomerulogenesis.

Absence of endothelial cells in abnormal glomeruli.

Glomerular capillary lumen was lost or interrupted, while larger renal vessels remained intact.

Conclusions:

VEGF is secreted by the Bowman's capsule.
VEGF acts in a paracrine manner to stimulate endothelial or progenitor cells.
VEGF is essential for the formation of the glomerular vasculature.