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Related Experiment Videos

Perfluoro compounds as artificial erythrocytes.

H A Sloviter

    Federation Proceedings
    |May 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Liquid perfluoro compounds can carry oxygen but cause lung lesions and fatal hypoxia in intact animals. Intravenous injection triggers clotting, leading to pulmonary hypertension and heart failure.

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    Transfusion·1991

    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Physiology
    • Respiratory Physiology

    Background:

    • Liquid perfluoro compounds exhibit high oxygen solubility and potential as erythrocyte substitutes.
    • Perfluoro compounds can be dispersed for various medical applications, including organ perfusion.

    Purpose of the Study:

    • To evaluate the efficacy and safety of dispersed perfluoro compounds as erythrocyte substitutes in physiological systems.
    • To investigate the adverse effects of intravenous administration of perfluoro compounds in intact animals.

    Main Methods:

    • Comparative analysis of oxygen-carrying capacity of perfluoro compounds versus erythrocytes under different gas compositions.
    • Assessment of perfluoro compound performance in perfusing isolated mammalian organs (brain, heart, kidney, lung, liver).

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  • Evaluation of physiological responses and survival rates following intravenous injection of dispersed perfluoro compounds in intact animal models.

    • Main Results:

    • Perfluoro compounds match erythrocyte oxygen content when equilibrated with 100% oxygen, but significantly less with alveolar air.
    • Dispersed perfluoro compounds adequately support perfusion in isolated organs.
    • Intravenous administration in intact animals leads to lung lesions, right heart dilation, and fatal hypoxia, likely due to intravascular clotting initiated by perfluoro particles.

    Conclusions:

    • While promising for isolated organ perfusion, dispersed perfluoro compounds pose significant risks for systemic circulation due to adverse pulmonary and cardiac effects.
    • Intravascular clotting and subsequent pulmonary pathology appear to be the primary mechanisms leading to adverse outcomes.
    • Further research is needed to mitigate these risks before clinical application as a blood substitute in vivo.